Shefali Jariwala, best remembered as the ‘Kaanta Laga Girl,’ passed away suddenly at the age of 42. The news came as a shock. Her husband, actor Parag Tyagi, rushed her to Bellevue Hospital in Mumbai on a Friday night, where she was declared brought dead.
Initial reports pointed to a suspected cardiac arrest. But what caught attention was something deeper: she had reportedly been fasting for a puja that day and had taken her regular pills and an anti-ageing injection on an empty stomach. According to preliminary police reports as per NDTV, this combination could have worsened her condition. Keep in mind that these might be speculations and unconfirmed reports, and the exact cause of Shefali Jariwala’s death will only be known after the official medical and forensic investigations are complete.
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As investigations continue, medical experts are now weighing in on the dangers of medications taken without food, especially in such delicate situations.
What happens when medications meet an empty stomach?
When pills or injections are taken without eating, they interact with the body in unusual ways. The stomach lining, left unprotected by food, becomes more vulnerable. Some medications, especially anti-inflammatory drugs, steroids, and certain supplements, can irritate this lining.

'Kaanta Laaga' girl Shefali Jariwala passed away at 42 from cardiac arrest.
Experts say this irritation doesn’t just cause heartburn or nausea. In sensitive cases, it can lower blood pressure suddenly, trigger shivering, or even lead to fainting. If the medication acts quickly, and the stomach is empty, the absorption might be too fast, causing an unexpected drop or spike in body responses like blood sugar or heart rate.
The role of anti-ageing injections and supplements
According to police reports, Shefali had taken an anti-ageing injection in the afternoon, a treatment she had been on for years, under supervision.
These injections contain compounds like glutathione, collagen boosters, or antioxidants that are administered intravenously or intramuscularly. While generally considered safe when prescribed, the body's response to them can change when the person is dehydrated or fasting.
Experts caution that such compounds, when taken on an empty stomach or in a fasted state, can sometimes stress the body’s systems, especially if combined with other daily medications.
Nowadays, a person suffers from multiple Disorders and hence is started on multiple medications. So the timing of medications is very important for their effective outcome and safety.Few medications need to be taken on an empty stomach, like few thyroid medications, medications for gastritis, some of the anti-tubercular medications, some anti-diabetics, etc., which help in the absorption of medications into the blood.While some medications should be avoided on an empty stomach, such as antibiotics, vitamins, mineral supplements, etc., which might cause gastric irritation/GI intolerance (nausea, vomiting). And some medications taken after food cause enhanced absorption.For example: iron supplements and medicines like allopurinol (used for gout) are taken after food, as they help reduce the risk of nausea/vomiting.Hence, one should follow the instructions prescribed by the doctors very strictly, as some medications need to be taken on an empty stomach for effective benefit and safety.
Dr Rishikesh Dessai, Consultant physician, Dept of Internal Medicine, Sir Gangaram Hospital, Delhi
Shefali had reportedly been fasting for a religious puja. While fasting is a respected and deeply spiritual practice, it does cause shifts in how the body functions.
Blood sugar tends to drop, electrolyte levels can fluctuate, and the body’s ability to buffer medications becomes weaker. If medicines that normally require food are consumed during a fast, their effects can become exaggerated or dangerously unpredictable.
In cases like Shefali’s, where injections and pills were taken during a fast, even a routine dosage could have contributed to the body going into shock or developing cardiac symptoms.
Studies have found that people who get high-dose vitamin C drips (more than 30 g intravenously) have lower blood pressure, especially if their baseline readings are higher. That effect happens because vitamin C relaxes blood vessels. This is usually safe, but if you're fasting and not getting enough fluids and salts, it can make the effect stronger, which can make you feel faint or dizzy or have dangerously low blood pressure.Medical experts warn that IV glutathione, which is used to lighten skin or slow down aging, can cause sudden reactions like allergic reactions, low blood pressure, trouble breathing, or kidney damage. Reports to the FDA say that some patients felt dizzy, sick, or had low blood pressure just a few minutes after the infusion.Glutathione is very important for keeping the electrical balance in heart cells. Low levels are linked to problems with heart rhythm. So, if a patient is already fasting and their electrolytes are changing, and then they get a vasoactive drip, this could theoretically cause sudden low blood pressure and unstable heart rhythms, which could lead to cardiac arrest, though this is very rare.These IV treatments are not just beauty hacks, they work like strong medications. Taking them while fasting can shock your body and make your blood pressure drop suddenly or your heart rhythm go wrong. It might look safe, but it's dangerous if you don't take care of it. Always consult a qualified doctor before undergoing such infusions, your health is never worth the gamble.
Dr. Rahul Mehrotra, Chief - NIC & Clinical Cardiology, Artemis Hospitals
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No foul play, but medical sensitivity under scanner
Police have found no foul play so far. Doctors at the hospital have not yet given a definitive cause of death. However, the circumstances, fasting, medication, and a sudden drop in blood pressure, are now prompting a deeper conversation about how such health routines can silently turn risky.
Forensic teams have collected samples of the medications and injections she took. Until toxicology reports are out, experts are urging caution: even well-meaning wellness habits like anti-ageing treatments or spiritual fasting should be balanced with careful medical planning.
[This article is based on preliminary reports and expert insights. It does not claim to confirm the exact cause of death of Shefali Jariwala. All medical observations in the article are general and should not replace personal medical advice. Inputs from agencies.]